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Our editors have researched and taken clean supplements for a decade — these are our picks for natural and organic options to support GLP-1 production.
With GLP-1s all the rage right now, we’ve been digging into the science to see what they actually are. You’ve probably heard about synthetic GLP-1 medications like Ozempic and Wegovy. Those were originally intended for use with diabetes and function by stimulating the release of insulin from the pancreas, which lowers blood sugar, as well as slowing the digestion of food in order to reduce appetite, which promotes weight loss. But did you know that there are supplements that can help support natural GLP-1 production and your overall metabolic health? The GLP-1 supplements on this list don’t contain synthetic GLP-1, instead they have natural ingredients that can help you feel healthier, more energized, and more regulated on a daily basis as you explore your health journey in all directions.
What is GLP-1 — and what does it do for your health?
GLP-1 is actually a natural hormone made in our gut that’s released after we eat, regulating the body’s appetite and blood sugar. GLP-1’s main responsibilities are to stimulate insulin secretion and to inhibit glucagon secretion, contributing to limit the rise and fall of glucose levels after meals. Beyond blood sugar control, GLP-1 has a pronounced satiety effect, slows down gastric emptying, and actually reduces postprandial insulin response. The GLP-1 hormone plays a big role in your metabolism and induces the feeling of satiety. Some research also points to some possible secondary benefits such as lowering blood pressure, improving lipid disorders, and improving fatty liver disease.
Who should consider supplementing for GLP-1 production?
GLP-1 medications, while originally intended for use in treating diabetes, have also been found to be incredibly helpful for weight loss and management. If you’re interested in the latest GLP-1 medications — but you’re looking for a more sustainable alternative without synthetic hormones and with fewer side effects — it could be a good time to discuss metabolic supplements with your healthcare provider.
What should you look for in natural GLP-1 supplements?
Natural GLP-1 supplements work by supporting your body’s existing ability to produce this hormone rather than introducing synthetic compounds. Brands like Ora, Pendulum, and the others on this list formulate their products using probiotic strains that help beneficial gut bacteria produce GLP-1 naturally, plant compounds that support metabolic function and satiety pathways, and nutrients that optimize the body’s natural hormone production processes. By combining these ingredient approaches, they tackle GLP-1 support from multiple angles.
Some of the ingredients you might see are probiotic strains like Akkermansia muciniphila, Clostridium butyricum, and Bifidobacterium infantis for supporting your gut health. Others will have OEA for cellular health and EGCG for supporting your gut. You’ll also see plant compounds like curcumin and saffron extract. We’ve noted the functional ingredients in each below so you can be sure about what you’re taking.
Our criteria:
We’ve personally taken, researched, and corresponded with the top clean supplement brands — these are our picks for the best GLP-1 supporting supplements on the market. We’ve chosen brands that use high-quality and effective clean ingredients, verified by third-party testing, to support metabolic health. We regularly update this list with new options that meet the following criteria:
- NATURAL & ORGANIC | The brands on this list use natural and organic ingredients to gently support your metabolic health with fewer side effects.
- CLEAN INGREDIENTS | All of our picks are third-party tested for any harmful or unnecessary additives so you can be sure you’re getting an effective and safe option.
- AFFORDABLE | The brands on this list offer a much more sustainable alternative to expensive medications, and many offer subscriptions to keep your costs even lower.
If you’re looking to invest in your overall health, check out our favorite women’s multivitamins (all tested by an editor!) and the best longevity supplements to keep you going for years to come.
1. Ora
Best For | Plant-powered formula
Functional Ingredients | Eriomin®, Morosil®, Reducose®, Feiolix®
Daily Dose | 2 capsules with your largest meal
Price per month | $60 with subscription
Ora’s GLP-1 Up stands out as a comprehensive plant-based approach to natural GLP-1 support, featuring four clinically studied ingredients designed to work across multiple metabolic pathways. Their formula includes Morosil red orange extract and Eriomin lemon extract, which clinical studies show can support post-meal blood sugar management by up to 40%. Ora’s commitment to whole-food nutrition and transparent sourcing sets them apart as an incredible choice. Ora offers a natural alternative to more intense GLP-1 treatments that supports your body’s own GLP-1 production without synthetic compounds. Their approach focuses on supporting satiety, minimizing energy crashes, and promoting efficient fat burning through botanical ingredients. So if you’re seeking a clean, plant-based option that aligns with your broader wellness values, Ora delivers a thoughtfully formulated supplement that works with your body’s natural processes — rather than against them.
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2. Pendulum
Best For | Probiotics for gut health
Functional Ingredients | Clostridium butyricum, Clostridium beijerinckii, Bifidobacterium infantis, Anaerobutyricum hallii, Akkermansia muciniphila
Daily Dose | 1 capsule with food
Price per month | $49 with subscription
Pendulum takes a uniquely scientific approach to GLP-1 support, focusing on the gut microbiome first and foremost, through their multi-strain probiotic formulation Metabolic Daily. Their formula features Akkermansia muciniphila — they are the only brand to offer this beneficial bacteria in a stable, live form. Their GLP-1 probiotic contains 500 million AFU of carefully selected strains including Clostridium butyricum and Bifidobacterium infantis. While results may take up to 3 months as the good bacteria need time to flourish, their 4-in-1 daily probiotic has the power to improve gut health, metabolism, mood, and energy simultaneously. Pendulum’s acid-resistant, delayed-release capsules ensure the live strains survive stomach acid and reach the gut microbiome intact. If you’re on the hunt for evidence-based formulations and understand that gut health is foundational to metabolic wellness, Pendulum offers natural GLP-1 support through targeted microbiome restoration.
Customer Review | “Very Visionary. A great deal of Science behind these Excellent Products.” – Sara (Read more reviews.)
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3. Veracity Selfcare
Best For | Clinical results
Functional Ingredients | Metabolaid®, green coffee bean extract, magnesium
Daily Dose | 2 capsules, 30 minutes before your first meal
Price per month | $64 with subscription
Veracity Selfcare’s Metabolism Ignite takes a research-first approach to natural GLP-1 support, featuring a plant polyphenol-based formula that’s clinically proven to help users lose 9 pounds in 90 days through targeted GLP-1 regulation, appetite control, and blood sugar management. Veracity Selfcare is so unique through their unwavering commitment to scientific validation, with 10 published studies including eight clinical trials demonstrating the effectiveness of their key ingredients at therapeutic dosage levels. The formula works by naturally boosting GLP-1 production to reduce appetite and cravings while supporting healthy metabolism, all without synthetic drugs or harsh side effects that come with prescription alternatives. Veracity emphasizes quality and safety through rigorous third-party testing for strength, composition, and purity. If you want a supplement with documented clinical outcomes, Veracity Selfcare offers one of the most scientifically validated approaches to all-natural GLP-1 support.
Customer Review | “This definitely works right away as an appetite suppressant and metabolism booster. I have friends getting injections and they experience such terrible side effects. This seems to be a better alternative that is beneficial to overall health.” – Erin (Read more reviews.)
4. Cymbiotika
Best For | Bioavailable formulas
Functional Ingredients | Oleoylethanolamide (OEA), Thiamin, Niacin, GlucoVantage® (dihydroberberine), EGCG
Daily Dose | 3 capsules, 30 minutes before your largest meal
Price per month | $60 with subscription
Cymbiotika’s Metabolic Health supplement shows their commitment to next-generation bioavailability with a specific standout ingredient: dihydroberberine. It’s five times more bioavailable than standard berberine and supports healthy blood sugar levels with fewer side effects. Their innovative approach to metabolic support focuses on enhanced fat metabolism, appetite control, and fat oxidation through carefully selected, clinically-backed ingredients. Cymbiotika’s pure, highly absorbable formulations maximize effectiveness while minimizing digestive discomfort often associated with traditional berberine supplements. Each serving is designed to be taken approximately 30 minutes before your largest meal of the day to work synergistically with your natural digestive processes. If you want a supplement that prioritized bioavailability and prioritizes efficiency in your routine, this could be the perfect choice for you.
Customer Review | “Started this supplement about a month ago. My Dr. is watching my blood sugar levels And she said to start these. It truly has taken away my cravings and I actually eat less. I can definitely say these work and I feel a huge difference! So excited to see the progress after a couple of months!” – Brooke (Read more reviews.)
5. Sakara
Best For | Food-based powder
Functional Ingredients | DygloFit®, chromium picolinate, cinnamon bark extract
Daily Dose | Blend 1 scoop with 8oz of hot water, coffee, or smoothie
Price per month | $76 with subscription
Sakara’s Metabolism Super Powder takes the pills out of the equation by combining metabolic support with luxurious lifestyle integration, featuring a delicious dark cacao flavor that transforms your daily wellness routine into a treat instead of chore! This carefully crafted powder contains potent plant-based ingredients including Gymnema sylvestre for sugar craving control, L-glutamine to protect gut barrier health, horsetail extract to reduce bloating and water retention, and black pepper piperine to enhance digestion and nutrient absorption. This isn’t just a supplement — it’s designed to seamlessly integrate into your existing lifestyle, mixed into smoothies, stirred into plant milk, or incorporated into other healthy recipes. This naturally rich, low-sugar formulation tastes delicious and indulgent while supporting weight management, curbing cravings, and controlling appetite. If you hate pills and don’t want to add another one into your routine, Sakara’s got you, girl!
Customer Review | “Tastes like a creamy chocolate milkshake, not chalky or artificial. Great with both water and a plant-based milk. I like the individual packets – they are great for travel!” – Ashley (Read more reviews.)
6. Hum Nutrition
Best For | Bloating relief
Functional Ingredients | Prebiotic fiber, ginger, peppermint leaf, and fennel seed
Daily Dose | Mix 4 tsps with 16 ounces of water with a meal
Price per month | $17 with subscription
Hum is a brand we all know and love for their beauty and health-supporting supplements, and they have something up their sleeve in the way of GLP-1 support, too! Hum’s Flatter Me Fiber GLP-1 Booster takes a refreshing approach to natural GLP-1 support through their clinically-backed prebiotic fiber designed to double GLP-1 levels naturally while simultaneously curbing cravings and promoting digestive regularity. The dual-action formula combines GLP-1 boosting benefits with their signature Flatter Me enzymes blend, designed to ease bloating and support optimal digestion within just 30 minutes. This innovative fiber powder comes in two yummy flavors — pineapple passion fruit and strawberry lemon, which you can mix into water, smoothies, or other beverages. Hum’s focus on targeted solutions makes this fiber particularly suitable for women dealing with both appetite control and digestive comfort issues simultaneously. If you already love their Flatter Me supplements, this choice might be a no-brainer!
Customer Review | “Fantastic product! This has really helped me stay more regular with my bowels and has really reduced my bloating. I drink it almost daily for the past 2 weeks and have noticed a significant difference. I would highly suggest for anyone that’s on the fence. It’ll change your life in such a good way. Hope you like it as much as I do!” – Ana (Read more reviews.)
7. Codeage
Best For | Affordability
Functional Ingredients | Clostridium butyricum, Akkermansia muciniphila, Bifidobacterium infantis, chicory inulin
Daily Dose | 1 capsule
Price per month | $10
Codeage’s GLP-1 Probiotic+ combines the best of both worlds with a GLP-1 boost and a potent 500 million AFU blend of carefully selected live probiotics, including Akkermansia muciniphila, Clostridium butyricum, and Bifidobacterium infantis. Their formula thoughtfully combines ingredients traditionally associated with prebiotics, probiotics, and postbiotics into one convenient capsule that can be taken with or without food, or even opened and mixed into beverages or smoothies. Their bottles come in a three-month supply, and are only $30, so if you’re on the hunt for a high quality budget-friendly option, this could be the best choice for you, as Codeage delivers premium ingredients at an accessible price point without compromising on efficacy or safety.
Customer Review | “I’ve been using this for just over a month and it really has helped curb my appetite! I still get some cravings but those seem to be more connected to emotional eating than anything else. I’m very satisfied with smaller portions and find it much easier to resist eating when I’m not hungry. I also feel like I stay full longer but this hasn’t slowed my digestion to the point of discomfort, which my sister has experienced taking GLP injections. This is working well for me at a much more reasonable price than the celebrity-endorsed similar product. Definitely reordering, and telling my friends about it, too!” – Liannel (Read more reviews.)
Jamie Kahn is a writer and yoga teacher based in New York. Her work has been featured in Glamour, Brooklyn Magazine, Epiphany, The Evergreen Review, and others.
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